Mixing doses of the Oxford/AstraZeneca and Pfizer/BioNTech vaccines generates a robust immune response against coronavirus, research suggests.

The study found that using Pfizer followed by Oxford or vice versa induced high concentrations of antibodies against the spike protein of the virus when doses were given four weeks apart.

The findings could allow flexibility in the UK and global vaccine rollouts, allowing people to receive whatever jab is available, rather than waiting for a matching one. However, given the UK’s vaccine supply position it is unlikely the schedule will change at the moment.

Professor Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford, and chief investigator on the trial, said: “The Com-COV study has evaluated ‘mix and match’ combinations of the Oxford and Pfizer vaccines to see to what extent these vaccines can be used interchangeably, potentially allowing flexibility in the UK and global vaccine rollout.

“The results show that when given at a four-week interval both mixed schedules induce an immune response that is above the threshold set by the standard schedule of the Oxford/AstraZeneca vaccine.

The Com-COV study, run by the University of Oxford, found that the order of vaccines made a difference. Oxford followed by Pfizer induced higher antibodies and T cell responses than Pfizer followed by Oxford.

But both schedules induced higher antibodies than the licensed, and highly effective, standard two-dose Oxford/AstraZeneca schedule.

The highest antibody response was seen after two doses of the Pfizer jab, and the highest T cell response from Oxford followed by Pfizer.

T cells play an important role in supporting and maintaining antibody production. Prof Snape said: “These results are an invaluable guide to the use of mixed dose schedules, however the interval of four weeks studied here is shorter than the eight to 12-week schedule most commonly used for the Oxford/AstraZeneca vaccine.

“This longer interval is known to result in a better immune response, and the results for a 12-week interval will be available shortly.”

Professor Andrew Ustianowski, National Institute for Health Research clinical lead for the Covid-19 vaccination programme and joint national infection specialty lead, said: “We know that the Oxford/AstraZeneca two-dose schedule is highly effective and has helped to save many lives.

“The fact we now know it works well, in terms of immune responses, when combined with the Pfizer vaccine provides researchers with the valuable knowledge that these vaccines could be used flexibly for those yet to be vaccinated in the UK and globally.”

The Com-COV study aims to evaluate the feasibility of using a different vaccine for the initial prime vaccination to the follow-up booster jab. The paper is published on the Lancet pre-print server.